Monday, December 31, 2012

Chapter Two Restaurant (Blackheath, London, by Blackheathcoffeeshops)

I really want to hate Chapters All Day Dining. I want to hate it because of its mass self-publicisation in the local free glossies. I want to hate it because on a Saturday evening it is full of fake tans, big zirconas and bleached hair posies who manage to make champagne look tacky.

I nearly really did hate it, because of its really unjust bread policy. Everyone around us was offered warm baked bread except for us. And this is not the first time. We cannot work out why we consistently fail to meet the deserving to be given bread when we have ordered.

So the food has yet to come, but I am well on track to achieve hatred of Chapters (with the exception of a good glass of grapefruit juice), and all my plans collapse into failure after the first chip. ?The first chip was undercooked... glee! But the burger was brilliant, really really burgery, and so were the rest of the chips and rocket and parmesan salad.

Source: http://www.qype.co.uk/review/3491511

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Broncos take top spot with 38-3 win over Chiefs

DENVER (AP) ? Peyton Manning figured one one-handed catch deserved another.

So, up the ladder he went ? throwing the ball high in the back of the end zone to Demaryius Thomas.

Thomas leaped and brought it down with his right hand, then got both feet down inside the line for a touchdown. With that, he joined Eric Decker in Denver's one-handed-touchdown club Sunday and gave the Broncos another otherworldly highlight to go with their home-field advantage throughout the playoffs after a 38-3 runaway over the Kansas City Chiefs.

"They claim they can do that all the time," said cornerback Champ Bailey, who got to watch the replays of both catches about a half-dozen times on the scoreboard. "They say they practice that. I don't see it. But as long as they do it on Sunday, I'm all for it. Those are some great, hard-working boys and I expect nothing less."

Manning, in search of his fifth MVP award and, yes, a second Super Bowl title, finished 23 for 29 for 304 yards, three scores and a 144.8 passer rating. One of his main competitors for the award, Adrian Peterson of the Vikings, ran for 199 yards to reach 2,097 for the season in a 37-34 win over Green Bay that secured a playoff berth.

That one went down to the wire. Manning was out of his game by the fourth quarter.

This was the second straight Sunday he used a grey-and-orange glove to prepare for the cold, playoff weather he could face at home the next two games.

"I threw it OK today, I guess," said Manning, who finished the season with 4,659 yards, 37 touchdowns and a 105.8 passer rating, all second best in his 15-year career.

Thanks to Houston's 28-16 loss to Indianapolis before the Broncos kicked off, Denver (13-3) will be the top seed for the sixth time. The Broncos made the Super Bowl four of the previous five times they've had home-field advantage.

Though the Chiefs (2-14) gave the Broncos as tough a tussle as anyone during their 11-game winning streak ? in a 17-9 loss last month ? this wasn't expected to be much of a game. It wasn't.

Leave it to Manning, ever the perfectionist, to ramp up the degree of difficulty.

On the 16-yard touchdown to Decker, Manning slightly overthrew the pass but Decker reached out with his left hand, brought the ball into his helmet, had it pinball against his facemask twice, then cradled it with both hands as he was falling to the ground.

"Peyton throws the ball up, giving us a chance to make a play. It's our job to catch it," Decker said.

The 13-yard touchdown to the 6-foot-3 Thomas mirrored a TD pass Manning threw to Decker last week against Cleveland: high in the back of the end zone where only his receiver could catch it.

"That was probably the limit right there," Manning said. "But I've seen him in practice. He can jump. He can really elevate. It's hard to throw it over his head, I'll say that."

The Thomas touchdown made it 28-3 and the celebration was on. The only trip the Broncos will have to make on their road to a championship would be to New Orleans for the Super Bowl. They'll open the playoffs at home Jan. 12 against Baltimore, Cincinnati or Manning's old team, the Colts.

Coach John Fox, in search of his second trip to the Super Bowl, won his 100th career game. Thomas and linebacker Wesley Woodyard congratulated him with a big splash of orange Gatorade at the end.

"It's an accomplishment, but it's something that was a lot of people's work. It wasn't one guy," Fox said.

Nor would Manning take all the credit for all he's accomplished in this, a comeback season in which he didn't know what to expect.

This marked his 73rd three-touchdown game, surpassing the record held by Brett Favre. Manning closed the regular season only 41 yards short of his career high.

"It's been a gratifying regular season," Manning said. "I will admit that. It is certainly more than I expected. I'm grateful and humble for it."

On the other end of the spectrum are the Chiefs, who, like the Broncos, had five Pro Bowlers on their roster, but finished with 119 yards of offense and wrapped up the first pick in next year's draft.

Coach Romeo Crennel watched the game from the sideline, leaning on a crutch, after having his knee drained of fluid earlier in the week. Many in Kansas City expect him to be unemployed soon.

"I told him it's been a long one," Chiefs defensive lineman Shaun Smith said about his postgame conversation with Crennel. "Sorry it didn't turn out the way (we wanted). I have faith in you and that's all that matters."

The Broncos swept their division games for the first time since 1998 ? the last time they won the Super Bowl.

John Elway retired after that one. Now, he's back, running Denver's front office, and he signed Manning with only one goal in mind: a third Lombardi Trophy.

For a brief glimmer, this could have been a game. The Broncos led 7-0 when Ronnie Hillman fumbled and Chiefs cornerback Brandon Flowers picked it up and was sprinting toward the end zone.

Manning cut off the Flowers return, allowing tight end Joel Dreessen to drag down Flowers at the 12. The Chiefs settled for a field goal and the Broncos scored the next 31 points.

Notes: Chiefs RB Jamaal Charles had 53 yards to finish the season with 1,509. ... Broncos FS Rahim Moore got his first career sack and Von Miller had one to bring his season total to 18?. ... Hillman wasn't seen against after his fumble. Lance Ball replaced him as Knowshon Moreno's backup and led the team with 66 yards on 15 carries.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/broncos-top-spot-38-3-win-over-chiefs-001542286--spt.html

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Top law professor quits Zimbabwe rights watchdog

HARARE, Zimbabwe (AP) ? The head of an independent but state-funded human rights commission says he has quit because of a lack of financial support and inadequate legislation empowering it to monitor the situation and punish violations.

Professor Reg Austin, an eminent law professor and expert on international and constitutional law, announced his departure Saturday.

In a statement, he likened the commission, set up under a democratic reform program in 2010, to "a baby for whose birth the parents made no preparations: no nursery, not cot, no blankets, no baby food."

An independent Zimbabwe lawyers group said Saturday the decision to quit by a lifelong campaigner for justice ahead of elections proposed next year confirmed the failure of President Robert Mugabe's government to end rights abuses after years of violations linked to elections.

Source: http://news.yahoo.com/top-law-professor-quits-zimbabwe-rights-watchdog-160432580.html

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Saturday, December 29, 2012

Lyft Staffing Up In Seattle And Los Angeles As It Looks To Expand Its Ride-Sharing Service Beyond SF

Lyft carLyft, the local on-demand ride-sharing service operated by the startup Zimride, is apparently not letting recent regulatory hurdles cramp its style too much. Lyft, which launched its service allowing individual car-owners to provide local transportation services to their peers in exchange for a suggested donation in San Francisco this past summer, is now actively recruiting staff in new cities including Seattle and Los Angeles as part of a planned geographic expansion in the new year.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/3U3AvVKEM4Y/

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Ryan Edwards to Maci Bookout: Marry Me!!

Source: http://www.thehollywoodgossip.com/2012/12/ryan-edwards-to-maci-bookout-marry-me/

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Taking Charge of Your Financial Debts Today for a Brighter Tomorrow

Nobody wants to be in debt.? But when you have a family, debt not only impacts your immediate lifestyle but it affects your children?s future.? As you spend more now, you may not be able to set money aside for them to attend college if every dime is going toward paying down debts.? If you have debt and are looking for ways to reduce it or become completely debt-free, use expert family debt advice to get your finances back in the black.

One of the most important pieces of advice you should heed is to approach debt settlement services with caution. If you need help getting your debt under control, there are other options you might want to consider.? Several reputable alternatives can be found here: http://www.usa.gov/topics/money/credit/debt/out-of-control.

You risk getting in even more financial trouble if you do not approach debt management in a smart manner.? Do your research so you know what to expect and what you should avoid.? Whatever you do, be sure to pay your mortgage or rent every month.? Your children need to have a stable environment as they grow up.? Identify every activity you do that will get you further in debt, and replace it with family activities.? You will be saving money and bonding with your children at the same time!

Source: http://www.familyfinancesource.com/family-budget/family-debt-advice/taking-charge-of-your-financial-debts-today-for-a-brighter-tomorrow

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US leaves C. African Republic amid security woes

BANGUI, Central African Republic (AP) ? Security concerns deepened in the capital of Central African Republic on Friday after the U.S. ambassador and his diplomatic team were evacuated out of the country by plane overnight amid fears rebels could try to take the capital.

U.S. officials said about 40 people were evacuated on an U.S. Air Force plane bound for Kenya. The officials spoke on condition of anonymity because they weren't authorized to discuss the details of the operation.

The evacuation came after President Francois Bozize on Thursday urgently called on former colonial ruler France and other foreign powers to help his government fend off rebels who are quickly seizing territory and approaching the capital.

The U.N.'s most powerful body condemned the recent violence and expressed concern about the developments.

"The members of the Security Council reiterate their demand that the armed groups immediately cease hostilities, withdraw from captured cities and cease any further advance towards the city of Bangui," the statement said.

Central African Republic has a history of violent change in government. The current president himself came to power nearly a decade ago in the wake of a rebellion in this resource-rich yet deeply poor country.

Speaking to crowds in Bangui, a city of some 600,000, Bozize pleaded with foreign powers to do what they could. He pointed in particular to France, Central African Republic's former colonial ruler. About 200 French soldiers are already in the country, providing technical support and helping to train the local army, according to the French defense ministry.

"France has the means to stop (the rebels) but unfortunately they have done nothing for us until now," Bozize said.

French President Francois Hollande said Thursday that France wants to protect its interests in Central African Republic and not Bozize's government. The comments came a day after dozens of protesters, angry about a lack of help against rebel forces, threw rocks at the French Embassy in Bangui and stole a French flag.

Paris is encouraging peace talks between the government and the rebels, with the French Foreign Ministry noting in a statement that negotiations are due to "begin shortly in Libreville (Gabon)." But it was not immediately clear if any dates have been set for those talks.

French Foreign Minister Laurent Fabius spoke via phone with Bozize, asking the president to take responsibility for the safety of French nationals and diplomatic missions in Central African Republic.

Bozize's government earlier reached out to longtime ally Chad, which pledged to send 2,000 troops to bolster Central African Republic's own forces.

This landlocked nation of some 4.4 million people has suffered decades of army revolts, coups and rebellions since gaining independence in 1960 and remains one of the poorest countries in the world.

The rebels behind the most recent instability signed a 2007 peace accord allowing them to join the regular army, but insurgent leaders say the deal wasn't fully implemented. The rebel forces have seized at least 10 towns across the sparsely populated north of the country, and residents in the capital now fear the insurgents could attack at any time, despite assurances by rebel leaders that they are willing to engage in dialogue instead of attacking Bangui.

The rebels have claimed that their actions are justified in light of the "thirst for justice, for peace, for security and for economic development of the people of Central African Republic."

Despite Central African Republic's wealth of gold, diamonds, timber and uranium, the government remains perpetually cash-strapped. Filip Hilgert, a researcher with Belgium-based International Peace Information Service, said rebel groups are unhappy because they feel the government doesn't invest in their areas.

"The main thing they say is that the north of the country, and especially in their case the northeast, has always been neglected by the central government in all ways," he said.

The rebels also are demanding that the government make payments to ex-combatants, suggesting that their motives may also be for personal financial gain.

___

Larson reported from Dakar, Senegal. Associated Press writer Sarah DiLorenzo in Paris contributed to this report.

Source: http://news.yahoo.com/us-leaves-c-african-republic-amid-security-woes-110411810.html

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Friday, December 28, 2012

Obama Calls Leaders as 'Cliff' Looms (WSJ)

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Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism

Dec. 27, 2012 ? Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas.

Researchers at the University of Exeter Medical School are the first in the world to utilise new genetic sequencing technology to sequence the entirety of a gene in order to identify mutations that cause hyperinsulinism. Previously, existing technology limited such sequencing to only part of the coding regions of the gene which meant that some mutations were missed.

Using new Illumina genetic sequencing technology, the research team led by Professor Sian Ellard has discovered novel mutations that cause hyperinsulinism. Their findings are published December 27 2012, on-line by The American Journal of Human Genetics.

The outcome will be that some infants born with hyperinsulinism will require fewer investigations, because the new technology means that for many only one genetic test will be required to determine the extent of the condition in each child. It also means that clinicians will have more information at their fingertips to inform them about how much of the pancreas needs to be removed.

Approximately 50 per cent of patients with congenital hyperinsulinism require surgery, and of those half require the entire pancreas to be removed. Removal of the entire pancreas increases the risk of diabetes later in life, but if left undiagnosed and untreated hyperinsulinism can result in irreparable brain damage. Symptoms range from shakiness and tiredness to seizure and coma.

Dr. Sarah Flanagan, Research Fellow in Molecular Genetics at the University of Exeter Medical School said: "The potential provided by this new technology is important and exciting, because it allows us to investigate genetic coding in its entirety. This means that investigators can identify mutations that sit at the heart of any number of conditions where before they might have been missed. This in turn results in better information for clinicians upon which they can base effective treatments and interventions for their patients."

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Story Source:

The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sarah?E. Flanagan, Weijia Xie, Richard Caswell, Annet Damhuis, Christine Vianey-Saban, Teoman Akcay, Feyza Darendeliler, Firdevs Bas, Ayla Guven, Zeynep Siklar, Gonul Ocal, Merih Berberoglu, Nuala Murphy, Maureen O?Sullivan, Andrew Green, Peter?E. Clayton, Indraneel Banerjee, Peter?T. Clayton, Khalid Hussain, Michael?N. Weedon, Sian Ellard. Next-Generation Sequencing Reveals Deep Intronic Cryptic ABCC8 and HADH Splicing Founder Mutations Causing Hyperinsulinism by Pseudoexon Activation. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2012.11.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Hvyf7POeyVQ/121227130325.htm

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Video: Where's Hillary?

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Thursday, December 27, 2012

Top ten Technologies Milestones Within 2006 THE Computers-and ...

Computer systems possess transformed the planet. The planet look at has become powered through cyber room as well as digital functioning? offers accepted pretty much every facet of existence through financial as well as industry in order to relationship, domestic pets, as well as relationship. Based on technology experts the entire year 2006 had been the switching point? for that THIS business.
Wind gusts associated with alter blew via just about all elements equipment, software program, as well as add-ons. Web put on a brand new layer and also the genX processors redefined Computers as well as their own working. Changeover had been the actual by-line as well as brand new systems as well as processors centered processing together with intro of the brand new era associated with units. Games arrived at for that heavens along with brand new technologies, add-ons, as well as futuristic video games.

One of the primary shades inside it had been several special milestones:

1. Landscape premiered as well as made welcome through a few as well as declined through other people. Preliminary responses had been good as well as business watchers possess used the wait around as well as see? plan prior to pronouncing views or even awards.

two. Linux obtained the necessary assistance through software program titans.

3. Search engines launched numerous proper improvements as well as bought Youtube . com being Absolutely no 1 within the cyber globe.

four. Dell remembered four zillion laptop computer electric batteries following reviews how the lithium-ion electric batteries might short-circuit as well as capture fireplace. Dells motion had been rapidly then additional top producers such as Apple company, lenovo, as well as Toshiba.

5. Technologies arrived at brand new levels along with movie loading, online films, AUDIO music, and much more. GenX computer systems as well as peripherals waved inside a brand new period associated with press amusement as well as understanding techniques.

6. Open up supply software program produced surf and also the entire business readied by itself for any brand new function purchase.

7. Video gaming units such as Xbox 360 console, Sony Perform channels, as well as Manufacturers thrilled game enthusiasts worldwide and also the brand new units required video gaming in the direction of brand new horizons.

8. Apple company created background using the release of the Macintosh Computer which operates upon Intel potato chips.

9. Hewlett packard had been rocked with a spy? scandal then the actual resignation associated with Chairman Patricia Dunn.

10. Ms noticed modifications along with Expenses Entrance leaving company actions to pay attention to philanthropic tasks.

Launched to the robust pc bazaar had been hi-tech images credit cards, crucial planks that may actually believe for you personally, cellular computer mouse which will follow whatever you order, video gaming add-ons, seem credit cards, image credit cards, earphones, pc furnishings, illumination, and much more.

Popularly called to become the entire year associated with alter with regard to processing as well as games, inch 2006 transformed how a globe recognized computer systems as well as the internet. The actual THIS as well as associated sectors are ready with regard to additional development and also the 12 months 2007 is actually ready in order to springtime several pleasures.

Posts related to Top ten Technologies Milestones Within 2006 THE Computers-and-Technology Post

Source: http://chaohuis.com/top-ten-technologies-milestones-within-2006-the-computers-and-technology-post.html

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Climate Model Coverage: Far from Model Journalism

November 2012 temperatures relative to average across the globe

November 2012 temperatures relative to average across the globe

With a less-than-stellar end to the Qatar climate talks, and with all eyes on the US for more ambitious commitments ahead of the next round, it is more important than ever for the American public to be better educated on the dire implications of a rapidly warming world.

Despite a recent shift toward greater belief in anthropogenic climate change, perception of its risks remains low among the US public.

A study published in the September issue of Nature Climate Change may help explain why. After analyzing climate coverage in major newspapers, and radio and television shows, the authors find a disproportionately large focus on op-ed and editorial topics in favor of actual explanations of science. The article concludes that the media not only provides insufficient scientific coverage, but also significantly undermines the reliability of climate models (in all news sources analyzed, almost two times the coverage of climate models was negative vs. positive).

Rather than merely focus on their imprecise nature, the media should take some time to elaborate on the complexity of computer models and shed light on why they are imprecise, describing what we know along with what we don?t know.

Reporting should emphasize that simulating the forces that drive climate, such as, ocean circulation and heat exchanges between land, air and sea, and their interactions with living ecosystems requires very sophisticated mathematical analysis. Systems of differential equations based on the laws of physics, fluid movement, and atmospheric chemistry take data from satellite observations, ocean buoys and other environmental monitoring equipment, which are then solved on supercomputers.

More importantly, these models entail dividing the Earth?s atmosphere into hundreds of thousands of grid points and predicting values for various physical factors, such as temperature, heat transfer, moisture content, and radiation at each grid point. The temperature at a given grid point is predicted five to 20 minutes at a time, until a projection far in the future, say the year 2100, is reached. Because of the short time-step of just a few minutes (which enables greater accuracy), even a one-year simulation would need to process this calculation tens of thousands of times; according to the World Meteorological Organization, for just one year, this would require processing 27,000 times for each of the 2.5 million grid points on Earth.

Climate models are by no means precise. Given their complexity, assumptions and simplifications have to be made to allow even supercomputers to generate projections in a reasonable amount of time. Nonetheless, they are rigorously mathematically tested, and data from past years have reliably been able to recreate the Ice Age and volcanic eruptions from past decades.

If the general public is given an intricate look at the processes that drive climate and the methods used to predict it, anyone with the ability to recall even a basic problem from middle school physics should begin to comprehend the sheer complexity of these projections. This will, perhaps, dispel the notion of climate scientists sitting in their labs and spewing conspiracy theories about a rapidly warming world.

In the aftermath of a political campaign where Republican candidates made a mockery of science, outrightly denying evolution, stem cell research, and human-induced climate change, it is even more important for the media to step up and defend science instead continuing to insist that there are two sides to this issue.

The fact that the Nature study found that The Rush Limbaugh Show provided the most ?explanation? of climate models among major news publications and programs should be disconcerting enough. More than a third of articles and shows explaining models were also seen to be in political commentary outlets.

Previous studies have called for greater transparency on the part of computer modelers in order to increase public trust in modeling. A paper that argues this in the Communications of the ACM aptly quotes the ?reasonable person doctrine?: ?information givers should provide enough information to takers for reasonable people to make decisions.?

Any less information is unacceptable, the authors state, since it does not give users the ability to make informed decisions, and instead forces them to place blind faith in the ?black box? that is computer modeling. The general public are users of information with regard to global warming, no doubt, because they make decisions everyday on energy consumption and carbon footprints: reusable vs. paper vs. plastic bags, energy-efficient vs. regular bulbs, cars vs. public transportation, and so on and so forth.

While all scientific issues suffer from perfunctory reporting due to lack of time, resources and expertise of journalists, climate change particularly lends itself well to the ?two sides to every issue? narrative, since so much of the research is still preliminary. And when the media encounters an event whose conclusion is unknown, it plays a guessing game, trying to predict a possible conclusion and argue for or against it, often based on little factual evidence (think presidential elections).

While this kind of coverage is corrosive anywhere, it?s even more so in the case of scientific stories, where it is important to report on the uncertainty itself rather than using it as a launching pad for pet theories.

Another reason the media gets it wrong is its endless thirst for the sensational, the controversial and the dramatic. Which is why controversies like Climate Gate or Rick Perry?s belief that global warming is a hoax make it to the front pages time and again.

Want dramatic?

Consider this reporting from Bloomberg Businessweek, accompanied by this very explicit cover page in the aftermath of Superstorm Sandy, which took nearly 200 lives and left millions without power on the East Coast:

?Sandy featured a scary extra twist implicating climate change. An Atlantic hurricane moving up the East Coast crashed into cold air dipping south from Canada. The collision supercharged the storm?s energy level and extended its geographical reach. Pushing that cold air south was an atmospheric pattern, known as a blocking high, above the Arctic Ocean. Climate scientists Charles Greene and Bruce Monger of Cornell University, writing earlier this year in Oceanography, provided evidence that Arctic icemelts linked to global warming contribute to the very atmospheric pattern that sent the frigid burst down across Canada and the eastern U.S.?

Since long-form journalism with context and background is now pass? in mainstream media, the media should at least take advantage of high-priority events like Sandy to shed light on the big picture. Unfortunately, these types of stories are exceedingly rare, but this is one way to educate audiences on the fact that computer models draw on the same logic that lies behind weather models, which most people rely on for their daily activities, and which are?unreliable-weatherman jokes aside?very close to accurate on a day-to-day basis.

Reporters could also make use of immersive multimedia technology to explain how models work, says Larry Pryor. Video games that allow people to ?play? with real simulations can give them firsthand experience in working with computer models.

Games could be specifically designed to allow users to see causes and effects, and to analyze the impact of various factors that affect global warming. The video game, SimCity, has a new version with an additional climate change component to be released next year.

Citizen science and crowdsourcing projects to model and predict climate change can also be great ways to enable the public to not only acquire information, but to also take part in the research. Old Weather, for example, is a crowdsourced effort aimed at gathering meteorological data from naval logs of?US ships from as far back as the mid-19th century, which can be used in climate models.

Initiatives like the Yale Project on Climate Change Communication are also great approaches to get citizens interested and involved in the climate debate. By tracking public awareness of climate change, including American attitudes, risk perceptions, and views on policies, the project tests new and effective ways to involve the public in climate science research.

Recent efforts to push for the teaching of climate science in schools, where children could learn the nuances, complexities and multidisciplinary aspects of climate research would make the job of the media easier, even while preparing the next generation of scientists and engineers who will likely address these challenges head on.

Meanwhile, the media should do its job. It?s the people?s right to know. If there were an impending terrorist attack or dangerous epidemic that could affect millions of people, surely the media would use every channel to communicate that to the public? What about global warming?a phenomenon that may cause entire coastlines to go under water and whole countries to disappear?doesn?t warrant communication?

Image: NOAA

Source: http://rss.sciam.com/click.phdo?i=99a8757a53f5533622f0c61e73846641

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Video: Year?s best products: Electronics, food, and more

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AIR UNDER DOOR A SIMPLE HOME IMPROVEMENT DIY | Home ...

27Dec

ON SOME SILLS THERE ADJUSTMENT SCREWS TO IMPROVE SEAL.KEEPING COLD AIR OUT OF YOUR HOUSE.THIS DOOR WAS INSTALLED IN 1993 ORIGINAL DOOR TO WHEN BUILDING WAS BUILT.improvement

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Source: http://www.cohocton.org/146-air-under-door-a-simple-home-improvement-diy

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Translation, Creativity and Creative Writing | Metaglossia

See on Scoop.it ? Metaglossia: The Translation World

wasafiri

A series of seminars organized by the OU?s Contemporary Cultures of Writing Research Group in collaboration with the Institute of English Studies, UL.

In the context of a Research Group (http://www.open.ac.uk/Arts/contemporary-cultures-of-writing/events.shtml) whose focus is on the cultures shaping contemporary modes of writing, this seminar series will look at the kinds of creativity involved in writing and translation with a view to highlighting the re-versioning and re-visioning at the heart of creative and literary endeavour. It will also seek to interrogate notions of translation both literal and metaphorical and to reflect on the challenges posed by multilingual writing and self-translation for both Creative Writing and Translation Studies.?
See on www.wasafiri.org

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Source: http://metaglossia.wordpress.com/2012/12/26/translation-creativity-and-creative-writing/

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Wednesday, October 31, 2012

Sky Garden House by Keiji Ashizawa Design | HomeDSGN, a daily ...

This contemporary, two-family residence was created by Keiji Ashizawa Design in 2010 and is located in Tokyo, Japan.

The house features a glass-enclosed air shaft running through its center to provide natural light while maintaining privacy from the outside.

Sky Garden House by Keiji Ashizawa Design:

?Sky Garden House is a two-family residence in central Tokyo. The main goal in design was to create an environment where two families can interact freely and frequently, while giving each family a high level of privacy from each other as well as from outside.

The peculiar nature of the location and limitations imposed by the building codes (in particular, the building-to-land ratio) presented considerable challenges in meeting this goal.

The house, where Clients and their two children occupy the first two floors and their parents live on the third floor, is built on a steep incline, with about 5 meters in height difference between the low and high points of the land, rendering part of the first floor effectively underground.

The building-to-land ratio required that maximum use of the available space be made to secure open, comfortable living space for two families. We and Clients sought to address these challenges through a series of extended discussions, in a process not unlike trying to piece together a complex puzzle.

In the end, we decided on three design features in meeting these challenges. First, we designed a light well and had each room face it. This had two benefits. One was that this would ensure that each room on the first three floors would receive good amount of sunlight. The other was that it would create an open and spacious feel to the house while allowing for privacy from outside environs.?

Photos by: Daici Ano

Source: http://www.homedsgn.com/2012/10/31/sky-garden-house-by-keiji-ashizawa-design/

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Friday, October 26, 2012

A Snapshot of Early Voting in 7 States

In 2008, about 30 percent of the national vote was cast via early or absentee ballots. This year, the expectation is that about 40 percent of Americans will cast a vote early, observers said.

"The big picture is [that] early voting is up," said Michael McDonald, director of the United States Elections Project. "More Republicans appear to be voting early [than in 2008], and Democrats are also voting early."

More than 7.7 million people nationwide have cast a ballot already, McDonald calculated.

There appear to be two reasons for the increase, he said.

First, the Romney campaign is doing a much better job of mobilizing the early vote than the McCain campaign did. The McCain campaign did very little to mobilize the early vote in 2008 and it was vastly outnumbered by the Obama campaign.

This cycle, the Republican National Committee reports that Republicans are making up a larger share of the early voters than they did last cycle - and they've put a comprehensive program in place with 119,000 volunteers who have made 44.8 million contacts total since the spring.

The other reason for the increase may be that voters find early voting convenient.

Here is a closer snapshot of where things stand in the battleground states where in-person early voting is allowed.

COLORADO

A total of 325,810 votes have been cast so far - 126,539 from registered Republicans and 120,965 from registered Democrats, plus 75,030 from "unaffiliated" voters.

FLORIDA

So far, 925,604 mail-in absentee ballots have been cast - 414,016 from Republicans and 363,881 from Democrats. Early in-person voting has not started yet in Florida. It kicks off on Saturday, Oct. 27.

IOWA

Voters have cast 399,858 ballots in the state - with 183,780 from Democrats and 126,872 from Republicans. Democrats currently have the advantage, but Republicans said they were performing much better than they were in Iowa at this point in 2008. At the same point in 2008, Democrats had about a 24-percentage-point lead in the early vote, Republicans said, whereas this year it's about 8 percentage points.

NEVADA

Democrats boast the advantage over Republicans - 101,935 to 79,058 - among the 218,616 votes cast so far statewide.

OHIO

A total of 808,051 ballots have been cast so far - with 618,861 absentee ballots returned and 189,190 additional in-person votes. Ohio does not register voters by party. Numbers are up in rural and urban counties, which bodes well for both Republicans and Democrats.

VIRGINIA

Virginia allows for in-person ballot casting ahead of Election Day - but state officials call it it in-person absentee voting and voters need an excuse to do it.

In any event, 247,862 votes already have been cast. The state does not register by party, but the Obama campaign reported earlier this week that more ballots have been cast in precincts Obama won than precincts McCain won. However, the Republican National Committee pointed out that absentee and early voter activity is down from 2008 in the Democratic counties of Alexandria, Arlington and Fairfax, and it's up in Republican-leaning Loudoun County.

WISCONSIN

Wisconsin is the great unknown. Every municipality in the state handles its election procedures differently. There are more local election officials in Wisconsin than in the entire rest of the country combined. As a result, the state doesn't report out complete numbers of their early and absentee votes as they come in. To make matters even more vague, voters don't register by party in Wisconsin either.

Also Read

Source: http://news.yahoo.com/snapshot-early-voting-7-states-100120878--abc-news-politics.html

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Thursday, October 25, 2012

Just bought an iPad 3? Check local return policy

14 hrs.

Even journalists and devoted Apple fans were a bit surprised at Tuesday's update of the full-size iPad; generally Apple's products are out at least a year or so before new versions?are announced. But what was merely perplexing for some may be downright infuriating for others, particularly those who just bought an iPad 3 thinking they were safe from obsolescence???for a few more months, anyway.

Some buyers may be in luck, however: As usual, anyone who bought their iPad from Apple in the last two weeks is within the return period, and CNET reports that at least one store is allowing returns for iPads bought as far as a month back as a conciliatory gesture.

This extended return period?hasn't been confirmed by Apple, although one consumer claims to have heard from Apple Care about it. I called an Apple Store in Seattle and they said they weren't doing the extended return period. The manager speculated that larger stores with more inventory might have more freedom to do it. Apple itself?has not responded to our?inquiries, but we will update this article if they get back to us.

There's no risk in calling your local Apple Store and asking, though. Just be sure that your 3rd-gen iPad is in mint condition: no etching, stickers, or wear and tear. Otherwise they won't take it in whether you bought it a month ago or this week.

Were you unlucky enough to you have bought?your iPad 3 just outside the window of return?opportunity? Don't be too put out. The new model got a speed boost and the new Lightning connector, but that's?all. The great screen and form factor are otherwise identical, so be assured you still have a solid tablet in your hands.

Devin Coldewey is a contributing writer for NBC?News Digital. His personal website is?coldewey.cc.

Source: http://www.nbcnews.com/technology/gadgetbox/just-bought-ipad-3-check-your-local-stores-return-policy-1C6643650

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Spain regulator halts sale of some Novartis flu vaccines

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Soundtrack to history: 1878 Edison audio unveiled

John Schneiter, a trustee at the Museum of Innovation and Science, talks about tinfoil phonographs on Wednesday, Oct. 24, 2012, in Schenectady, N.Y. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. Recorded on a sheet of tinfoil on a phonograph invented by Thomas Edison, the recording was made in St. Louis in 1878. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

John Schneiter, a trustee at the Museum of Innovation and Science, talks about tinfoil phonographs on Wednesday, Oct. 24, 2012, in Schenectady, N.Y. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. Recorded on a sheet of tinfoil on a phonograph invented by Thomas Edison, the recording was made in St. Louis in 1878. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

This photo provided by the Museum of Innovation and Science in Schenectady, N.Y., shows Thomas Edison's 1878 tinfoil phonograph. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. Recorded on a sheet of tinfoil on a phonograph invented by Thomas Edison, the recording was made in St. Louis in 1878. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

Chris Hunter, curator at the Museum of Innovation and Science, plays a 1878 tinfoil recording on a computer on Wednesday, Oct. 24, 2012, in Schenectady, N.Y. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. Recorded on a sheet of tinfoil on a phonograph invented by Thomas Edison, the recording was made in St. Louis in 1878. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

A tinfoil sheet recording made on a phonograph which was invented by Thomas Edison and recorded in St. Louis in 1878 is displayed at the Museum of Innovation and Science on Wednesday, Oct. 24, 2012, in Schenectady, N.Y. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

A tinfoil sheet recording made on a phonograph which was invented by Thomas Edison and recorded in St. Louis in 1878 is displayed at the Museum of Innovation and Science on Wednesday, Oct. 24, 2012, in Schenectady, N.Y. Researchers have digitized what experts say is the oldest recording of a playable American voice and history?s first-ever recorded musical performance, along with the first recorded blooper. It contains a short coronet solo of an unidentified song, followed by the voices of a man reciting popular nursery rhymes. (AP Photo/Mike Groll)

SCHENECTADY, N.Y. (AP) ? It's scratchy, lasts only 78 seconds and features the world's first recorded blooper.

The modern masses can now listen to what experts say is the oldest playable recording of an American voice and the first-ever capturing of a musical performance, thanks to digital advances that allowed the sound to be transferred from flimsy tinfoil to computer.

The recording was originally made on a Thomas Edison-invented phonograph in St. Louis in 1878.

At a time when music lovers can carry thousands of digital songs on a player the size of a pack of gum, Edison's tinfoil playback seems prehistoric. But that dinosaur opens a key window into the development of recorded sound.

"In the history of recorded sound that's still playable, this is about as far back as we can go," said John Schneiter, a trustee at the Museum of Innovation and Science, where it will be played Thursday night in the city where Edison helped found the General Electric Co.

The recording opens with a 23-second cornet solo of an unidentified song, followed by a man's voice reciting "Mary Had a Little Lamb" and "Old Mother Hubbard." The man laughs at two spots during the recording, including at the end, when he recites the wrong words in the second nursery rhyme.

"Look at me; I don't know the song," he says.

When the recording is played using modern technology during a presentation Thursday at a nearby theater, it likely will be the first time it has been played at a public event since it was created during an Edison phonograph demonstration held June 22, 1878, in St. Louis, museum officials said.

The recording was made on a sheet of tinfoil, 5 inches wide by 15 inches long, placed on the cylinder of the phonograph Edison invented in 1877 and began selling the following year.

A hand crank turned the cylinder under a stylus that would move up and down over the foil, recording the sound waves created by the operator's voice. The stylus would eventually tear the foil after just a few playbacks, and the person demonstrating the technology would typically tear up the tinfoil and hand the pieces out as souvenirs, according to museum curator Chris Hunter.

Popping noises heard on this recording are likely from scars left from where the foil was folded up for more than a century.

"Realistically, once you played it a couple of times, the stylus would tear through it and destroy it," he said.

Only a handful of the tinfoil recording sheets are known to known to survive, and of those, only two are playable: the Schenectady museum's and an 1880 recording owned by The Henry Ford museum in Michigan.

Hunter said he was able to determine just this week that the man's voice on the museum's 1878 tinfoil recording is believed to be that of Thomas Mason, a St. Louis newspaper political writer who also went by the pen name I.X. Peck.

Edison company records show that one of his newly invented tinfoil phonographs, serial No. 8, was sold to Mason for $95.50 in April 1878, and a search of old newspapers revealed a listing for a public phonograph program being offered by Peck on June 22, 1878, in St. Louis, the curator said.

A woman's voice says the words "Old Mother Hubbard," but her identity remains a mystery, he said. Three weeks after making the recording, Mason died of sunstroke, Hunter said.

A Connecticut woman donated the tinfoil to the Schenectady museum in 1978 for an exhibit on the 100th anniversary of the founding of the Edison company that later merged with another to form GE. The woman's father had been an antiques dealer in the Midwest and counted the item among his favorites, Hunter said.

In July, Hunter brought the Edison tinfoil recording to California's Berkeley Lab, where researchers such as Carl Haber have had success in recent years restoring some of the earliest audio recordings.

Haber's projects include recovering a snippet of a folk song recorded a capella in 1860 on paper by Edouard-Leon Scott de Martinville, a French printer credited with inventing the earliest known sound recording device.

Haber and his team used optical scanning technology to replicate the action of the phonograph's stylus, reading the grooves in the foil and creating a 3D image, which was then analyzed by a computer program that recovered the original recorded sound.

The achievement restores a vital link in the evolution of recorded sound, Haber said. The artifact represents Edison's first step in his efforts to record sound and have the capability to play it back, even if it was just once or twice, he said.

"It really completes a technology story," Haber said. "He was on the right track from the get-go to record and play it back."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-25-Edison-Found%20Sound/id-ba7726f867d74e42b7b54cf9098645c0

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Wine & Spirits: Train's Save Me, San Francisco Wines | Washington ...

The Grammy-winning band just released the fourth offering in its award-winning California wine line.

By Kelly A. Magyarics

Jimmy Stafford isn?t used to performing live without his pre-show glass or two of red wine.

The guitarist for the Grammy-award winning band Train, whose hits include ?Drive By? and ?Meet Virginia,? always gets his head in the game with a generous pour of Cab or Merlot. (For the record, he prefers to quench his thirst after concerts with a well-chilled Chardonnay.)

But since Saturday evening?s show took place at the Charles E. Smith Center on the campus of George Washington University?a dry campus?he had to forego his essential touring ritual. ?I think this is the first show?I?ve?ever done where I?didn?t?drink wine beforehand,? he admitted.

Certainly, Stafford?s forced abstaining?didn?t?affect the energy of the show. The band performed in front of an enthusiastic, eclectic mix of college students and their middle-

Train drummer Jimmy Stafford with the author. (Photo by Kristen Schopp)

aged parents, with some younger siblings thrown in for good measure. Train barreled through all of its hits, from the ubiquitously popular ?Hey, Soul Sister? to the ethereal ballad ?Drops of Jupiter,? to the Mariachi-inspired current single ?50 Ways to Say Goodbye.? Lead singer Pat Monahan not only gave us his soulful voice for the evening, but also tossed out dozens of signed t-shirts and beach balls; he also graciously posed with fans for cell phone pics and Tweets.

I caught up with Stafford, Monahan and drummer Scott Underwood backstage before their recent show on October 20, part of Colonial Days / Parents? Weekend at GWU, to chat about their successful wine line ?Save Me, San Francisco? (the moniker refers to the name of the band?s 2009 album and single.) Currently, the band produces three reds and a white in collaboration with Concannon Vineyard and winemaker James Foster of The Wine Group.

Train currently offers four wines in its popular Save Me, San Francisco line. (Photo by Save Me, San Francisco Wines)

Stafford and Monahan are fellow wine geeks. (In fact, when I introduced myself before the show as a wine writer, Monahan enthusiastically declared that he?d ?be happy to talk the sh*t out of some wine.?) They were adamant about doing it right though, and not resorting to gimmicky, celebrity wines . That philosophy has certainly worked for them: Train?s wines have won gold medals at the San Francisco International Wine Competition, and the Orange County Fair Wine Competition.

Their California 37 is a fruit-forward yet intense Cabernet Sauvignon that reminds Stafford and crew of the wines they used to drink in their early days as a band; the pineapple, buttery and vanilla notes found in Calling All Angels appeals to lovers of supple, luscious Chardonnays; Drops of Jupiter is a Petit Sirah-based blend that is fruity, low in tannins and (in my opinion) works slightly chilled, as you would a Beaujolais.

Train?s latest wine is a varietal bottled Merlot called Hella Fine Merlot, with cherry and chocolate aromas and medium tannins. Stafford told me that the first three Merlots sent to him for approval were too astringently tannic; he went with door number four, a wine that?s approachable, both with and without food. In the Washington, D.C. area, you can buy Save Me San Francisco Wines at Whole Foods Markets. It?s also on the menu at Bonefish Grill, and Ruth?s Chris Steak House.

The band has other wines in the works, including Soul Sister Pinot Noir, and Sweet Rain, a semi-sweet, Moscato-based bottle. Stafford approves not only the wines, but also the names and labels. And they have recently partnered with Ghiradelli Chocolate to produce sweet pairings like Dark Cabernet, Sea Salt Almond and 72% Cacao Dark Chocolate.

A portion of all the proceeds of wine sales (and all the profits from chocolate sales) goes to help Family House, a non-profit guest house in San Francisco that provides temporary housing to families of patients at the UCSF Benioff Children?s Hospital.

Kelly Magyarics is a wine and spirits writer, and wine educator, in the Washington, D.C. area. She can be reached through her website, www.kellymagyarics.com, or on www.twitter.com/kmagyarics.

Source: http://www.washingtonlife.com/2012/10/24/wine-spirits-trains-save-me-san-francisco-wines/

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Wednesday, October 24, 2012

Lactation protein suppresses tumors and metastasis in breast cancer

ScienceDaily (Oct. 24, 2012) ? A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology.

"This is the first confirmed report that this protein, called Elf5, is a tumor suppressor in breast cancer," explains Satrajit Sinha, PhD, associate professor of biochemistry in the UB School of Medicine and Biomedical Sciences and a corresponding author on the paper with Yibin Kang, PhD, in the Department of Molecular Biology at Princeton University.

The researchers say the findings provide new avenues to pursue in treating and diagnosing breast cancer and possibly cancers of other organs as well. The paper includes findings from both animal and human breast cancer models.

Under normal circumstances, Elf5 is a transcription factor that controls the genes that allow for milk production.

But when the researchers used knockout mice developed at UB, in whom Elf5 was removed, they found more than just an inability to produce milk. They found that epithelial cells in the mammary glands also became more mesenchymal, that is, more like stem cells, an early harbinger of cancer, Sinha says.

"We found that when Elf5 levels are low or absent, epithelial cells become more like stem cells, morphing into mesenchymal cells, changing their shape and appearance and migrating elsewhere in the body," says Sinha. "This is how cancer spreads."

The UB-Princeton collaboration began when lead author Rumela Chakrabarti, PhD, originally a postdoctoral researcher in Sinha's laboratory at UB, took a position in the laboratory of Yibin Kang, PhD, Warner-Lambert/Parke-Davis Professor of Molecular Biology at Princeton, whose research focus is breast cancer metastasis. This allowed Chakrabarti to harness the expertise of the two laboratories to generate such a breakthrough finding.

"Elf5 keeps normal breast cells in their current shape and restricts their movement," says Chakrabarti. She found that the protein accomplishes this by suppressing the epithelial-mesenchymal transition by directly repressing transcription of Snail2, a master regulator of mammary stem cells known to trigger the EMT.

"Elf5 keeps Snail2 repressed, but once Elf5 is lost, then there is nothing to repress Snail 2," she explains.

The paper notes that Elf5 loss is frequently detected early in the disease at the breast hyperplasia stage, when the number of cells increases. In experiments conducted by the Princeton scientists, the researchers also found that little or no Elf5 in human breast cancer samples correlated with increased morbidity.

"It seems that loss of Elf5 is an initial event in the disease, so it could also be an important diagnostic tool," Sinha notes, which is a current focus of the UB and Princeton team.

"We want to know, how early does the loss of Elf5 occur? Could we use loss of Elf5 as a reliable diagnostic tool?" he asks.

The finding reveals the complex pathways through which breast cancers develop, he says, while also providing new avenues to pursue for diagnostics and treatments.

"Our research shows that the EMT-Snail 2 pathway is a valuable one to target for early breast cancer intervention," says Sinha, "possibly by designing something to recapture the repressive effect of Elf5 or a drug that could mimic Elf5 activity. And this is just one molecule, part of a big network. That's why we are now creating a detailed map of this molecule and its associated partners in order to give us a better idea of what to look for."

Other UB co-authors on the paper are Rose-Anne Romano, PhD, research assistant professor in biochemistry, and Kirsten Smalley, research technician. Other coauthors are: Julie Hwang, Mario Andres Blanco, Martin Lukacisin and Yong Wei from Princeton; Song Liu of Roswell Park Cancer Institute; Qifeng Yang and Bruce F. Haffty of the Department of Radiation Oncology in the University of Medicine and Dentistry of New Jersey and the Cancer Institute of New Jersey; and Toni Ibrahim, Laura Mercatali and Dino Amadori of the Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori in Italy.

The research was supported by the National Institutes of Health, the Department of Defense, Komen for the Cure, the Brewster Foundation and the Champalimaud Foundation.

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Story Source:

The above story is reprinted from materials provided by University at Buffalo, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Rumela Chakrabarti, Julie Hwang, Mario Andres Blanco, Yong Wei, Martin Luka?i?in, Rose-Anne Romano, Kirsten Smalley, Song Liu, Qifeng Yang, Toni Ibrahim, Laura Mercatali, Dino Amadori, Bruce G. Haffty, Satrajit Sinha, Yibin Kang. Elf5 inhibits the epithelial?mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nature Cell Biology, 2012; DOI: 10.1038/ncb2607

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/7X9jNEk8Njk/121024101531.htm

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